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Carolyn B. Coyne, PhD



Dr. Carolyn Coyne

Contact

412-383-5149
427 Bridgeside Point II
450 Technology Drive

Education

Post-doctoral, Department of Microbiology, University of Pennsylvania

PhD in Pharmacology, University of North Carolina, Chapel Hill

BS in Biochemistry, Florida State University


Academic Affiliation(s)

Associate Professor, Department of Microbiology and Molecular Genetics
Member, Magee Women's Research Institute (MWRI)
Member, University of Pittsburgh Cancer Institute (UPCI)

Research

The research in my lab combines important aspects of virology, immunology, and cell biology to dissect various aspects of host-virus interactions, with a particular focus on polarized cell types. In particular, we focus on—(1) on the mechanisms by which enteroviruses have evolved to successfully circumnavigate the barriers presented by polarized cells to facilitate virus entry, replication, and spread, (2) on the mechanisms utilized by enteroviruses to evade and/or suppress innate immune signaling,  (3) on the identification of novel regulators and components of the innate immune system, and (4) on the role of placental-specific microRNAs in antiviral signaling and the induction of autophagy at the maternal-fetal interface.

Lab Personnel

Avi Bayer, graduate student
Elizabeth Delorme-Axford, postdoctoral fellow
Coyne Drummond, graduate student
Katharine Harris, graduate student
Jana Jacobs, graduate student
Stefanie Morosky, laboratory technician
Qian Shu, visiting Tsinghua scholar

Areas of Interest

Host-pathogen interactions; Innate Immune Signaling

Publications

Delorme-Axford E, Sadovsky Y, Coyne C. B. Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts. J Virol. 87: 8569-8581. |  View Abstract

Delorme-Axford E, Donker R. B, Mouillet J. F, Chu T, Bayer A, Ouyang Y, Wang T, Stolz D. B, Sarkar S. N, Morelli A. E, Sadovsky Y, Coyne C. B. Human placental trophoblasts confer viral resistance to recipient cells. Proc Natl Acad Sci USA. 110: 12048-12053. |  View Abstract

Bozym R. A, Delorme-Axford E, Harris K, Morosky S, Ikizler M, Dermody T. S, Sarkar S. N, and Coyne C. B. Focal adhesion kinase is a component of RIG-I-like receptor antiviral signaling. Cell Host Microbe. 11: 153-166. |  View Abstract

Mukherjee A, Morosky S. A, Delorme-Axford E, Dybdahl-Sissoko N, Oberste M. S, Wang T, and Coyne C. B. The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling. PLoS Pathog. 7: e1001311. |  View Abstract

Coyne C. B, Bozym R, Morosky S. A, Hanna S. L, Mukherjee A, Tudor M, Kim K. S, Cherry S. Comparative RNAi screening reveals host factors involved in enterovirus infection of polarized endothelial monolayers. Cell Host Microbe. 9: 70-82. |  View Abstract

Bozym R. A, Patel K, White C, Cheung K. H, Bergelson J. M, Morosky S. A, and Coyne C. B. Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells. Mol Biol Cell. 22: 3010-3021. |  View Abstract

Bozym R. A, Morosky S. A, Kim K. S, Cherry S, and Coyne C. B. Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells. PLoS Pathog. 6: e1001135. |  View Abstract