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Kate D. Ryman, PhD








				

		Dr. Kate Ryman	
		

		    	
        
Contact
        
	
					

			ryman@cvr.pitt.edu	
			

		
					

			412-624-3667	
			

			
        		

		Fax: 412-624-4440	
		

		
		
					
8036 Biomedical Science Tower 3
3501 Fifth Avenue
		
        
                
        







	

	
Education
PhD in Virology, University of Surrey (UK)
	



    




	

		
Academic Affiliation(s)

	
Associate Professor, Department of Microbiology and Molecular Genetics
Member, Center for Vaccine Research
Member, Molecular Virology and Microbiology Graduate Program
	
	







Research
My laboratory studies enveloped RNA viruses from the families Flaviviridae and Togaviridae, many of which are classified as potential agents of biowarfare/bioterrorism and emerging infectious disease by NIH/NIAID and/or CDC because they are highly pathogenic in humans, but typically there are no effective antivirals or licensed vaccines available. Our specific focus is on developing a better understanding of the way in which the early virus-host interaction shapes the outcome of infection. As our understanding of the host-pathogen interaction increases, we believe it will be possible to rationally design antiviral drugs for acute phase therapy and live attenuated virus strains that can be used as vaccines.



















Publications
	

	
Gardner C. L, and Ryman K. D. Yellow fever: a reemerging threat. Clin Lab Med. 30: 237-260. |  View Abstract
Meier K. C, Gardner C. L, Khoretonenko M. V, Klimstra W. B, and Ryman K. D. A mouse model for studying viscerotropic disease caused by yellow fever virus infection. PLoS Pathog. 5: e1000614. |  View Abstract
Burke C. W, Gardner C. L, Steffan J. J, Ryman K. D, and Klimstra W. B. Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses. Virology. 395: 121-132. |  View Abstract
Yin J, Gardner C. L, Burke C. W, Ryman K. D, and Klimstra W. B. Similarities and differences in antagonism of neuron alpha/beta interferon responses by Venezuelan equine encephalitis and Sindbis alphaviruses. J Virol. 83: 10036-10047. |  View Abstract
Gardner C. L, Yin J, Burke C. W, Klimstra W. B, and Ryman K. D. Type I interferon induction is correlated with attenuation of a South American eastern equine encephalitis virus strain in mice. Virology. 390: 338-347. |  View Abstract
Ryman K. D, and Klimstra W. B. Host responses to alphavirus infection. Immunol Rev. 225: 27-45. |  View Abstract
Gardner C. L, Burke C. W, Tesfay M. Z, Glass P. J, Klimstra W. B, Ryman K. D. Eastern and Venezuelan equine encephalitis viruses differ in their ability to infect dendritic cells and macrophages: impact of altered cell tropism on pathogenesis. J Virol. 82: 10634-10646. |  View Abstract