Carolyn B. Coyne, PhD
Education
Post-doctoral, Department of Microbiology, University of Pennsylvania
PhD in Pharmacology, University of North Carolina, Chapel Hill
BS in Biochemistry, Florida State University
Academic Affiliation(s)
Associate Professor, Department of Pediatrics
Member, Magee Women's Research Institute (MWRI)
Member, University of Pittsburgh Cancer Institute (UPCI)
Research
The research in my lab combines important aspects of virology, immunology, and cell biology to dissect various aspects of host-virus interactions, with a particular focus on polarized cell types. In particular, we focus on—(1) on the mechanisms by which enteroviruses have evolved to successfully circumnavigate the barriers presented by polarized cells to facilitate virus entry, replication, and spread, (2) on the mechanisms utilized by enteroviruses to evade and/or suppress innate immune signaling, (3) on the identification of novel regulators and components of the innate immune system, and (4) on the role of placental-specific microRNAs in antiviral signaling and the induction of autophagy at the maternal-fetal interface.
Lab Personnel
Avi Bayer, graduate student
Elizabeth Delorme-Axford, postdoctoral fellow
Coyne Drummond, graduate student
Katharine Harris, graduate student
Jana Jacobs, graduate student
Stefanie Morosky, laboratory technician
Qian Shu, visiting Tsinghua scholar
Areas of Interest
Host-pathogen interactions; Innate Immune Signaling
Publications
Delorme-Axford E, Sadovsky Y, Coyne C. B. Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts. J Virol. 87: 8569-8581. | View Abstract
Delorme-Axford E, Donker R. B, Mouillet J. F, Chu T, Bayer A, Ouyang Y, Wang T, Stolz D. B, Sarkar S. N, Morelli A. E, Sadovsky Y, Coyne C. B. Human placental trophoblasts confer viral resistance to recipient cells. Proc Natl Acad Sci USA. 110: 12048-12053. | View Abstract
Bozym R. A, Delorme-Axford E, Harris K, Morosky S, Ikizler M, Dermody T. S, Sarkar S. N, and Coyne C. B. Focal adhesion kinase is a component of RIG-I-like receptor antiviral signaling. Cell Host Microbe. 11: 153-166. | View Abstract
Mukherjee A, Morosky S. A, Delorme-Axford E, Dybdahl-Sissoko N, Oberste M. S, Wang T, and Coyne C. B. The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling. PLoS Pathog. 7: e1001311. | View Abstract
Coyne C. B, Bozym R, Morosky S. A, Hanna S. L, Mukherjee A, Tudor M, Kim K. S, Cherry S. Comparative RNAi screening reveals host factors involved in enterovirus infection of polarized endothelial monolayers. Cell Host Microbe. 9: 70-82. | View Abstract
Bozym R. A, Patel K, White C, Cheung K. H, Bergelson J. M, Morosky S. A, and Coyne C. B. Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells. Mol Biol Cell. 22: 3010-3021. | View Abstract
Bozym R. A, Morosky S. A, Kim K. S, Cherry S, and Coyne C. B. Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells. PLoS Pathog. 6: e1001135. | View Abstract
Spotlight
Meet the new MVM Program Director, Dr. Fred Homa!
