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Patrick S. Moore, MD, MPH








				

		Dr. Pat Moore	
		

		    	
        
Contact
        
	
					

			psm9@pitt.edu	
			

		
					

			412-623-7721	
			

			
        
		
					
1.9 Hillman Cancer Center
5117 Center Avenue
		
        
        			

			My Website >	
			

		        
        







	

	
Education
MPH, University of California, Berkeley
MD and MPhil, University of Utah
MS, Stanford University
BS, Westminster College
	



    




	

		
Academic Affiliation(s)

	
Distinguished and American Cancer Society Professor, Department of Microbiology and Molecular Genetics
Director, UPCI Cancer Virology Program
	
	







Research
Our work involves understanding how two different human cancer viruses we discovered (KSHV and MCV) initiate tumors.  We also seek to identify other undiscovered human cancer viruses.
Lab Personnel
Lab Co-director: Professor Yuan Chang, Pathology
Areas of Interest
Tumor virology, cap-dependent translation, virus targeting of human tumor suppressor pathways



















Publications
	

	
Velasquez C, Cheng E, Shuda M, Lee-Oesterreich P.J, Pogge von Strandmann L, Gritsenko M.A, Jacobs J.M, Moore P.S. and Chang Y. Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation. Proc Natl Acad Sci USA. 113: 8644-8471. |  View Abstract
Toptan T, Yousem S.A, Ho J, Matsushima Y, Stabile L.P, Fernandez-Figueras M.T, Bhargava R, Ryo A, Moore P.S. and Chang Y. Survey for human polyomaviruses in cancer. JCI Insight. 1: e85562. |  View Abstract
Shuda M, Velasquez C, Cheng E, Cordek D.G, Kwun H.J, Chang Y. and Moore P.S. CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci USA. 112: 5875-5882. |  View Abstract
Wendzicki J.A, Moore P.S. and Chang Y. Large T and small T antigens of Merkel cell polyomavirus. Curr Opin Virol. 11: 38-43. |  View Abstract
Kwun H.J, Shuda M, Camacho C.J, Gamper A.M, Thant M, Chang Y. and Moore P.S. Restricted protein phosphatase 2A targeting by Merkel cell polyomavirus small T antigen. J Virol. 89: 4191-4200. |  View Abstract
Chang Y. and Moore P.S. Twenty years of KSHV. Viruses. 6: 4258-4264. |  View Abstract
Li Z, Ender C, Meister G, Moore P. S, Chang Y, and John B. Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs. Nucleic Acids Res. 40: 6787-6799. |  View Abstract