MD, University of Utah
BS, Stanford University
Distinguished Professor of Pathology, Deptartment of Pathology
Distinguished Professor of Pathology, Cancer Virology Program, University of Pittsburgh Cancer Institute
Our laboratory performs basic and applied research on viral oncogenesis with efforts focused in three areas.
- Merkel cell carcinoma and Merkel cell polyomavirus. We recently discovered a new human polyomavirus, that we call Merkel cell polyomavirus (MCV). This virus is etiologically associated with a rare, but one of the most clinically aggressive skin cancers in humans. We are involved in the primary characteristics of this virus including transcript mapping, transforming properties, origin replication, transmission, and seroepidemiologic studies.
- Kaposi’s sarcoma-associated herpesvirus. We are investigating biologic properties of KSHV, the eighth human herpesvirus, also identified in our laboratory. KSHV causes Kaposi’s sarcoma, the most common AIDS-associated malignancy as well as a B-cell lymphoma. Through extensive molecular piracy, the virus has incorporated numerous genes which affect cell proliferation pathways, apoptosis, cell cycle regulation and immune modulation.
- New Pathogen Discovery. We continue to be interested in the search for new pathogens in human diseases and have developed new methodologies which utilize information gained from the Human Genome Project as well as advanced sequencing technologies.
Masahiro Shuda, Ph.D., Assistant Research Professor
Huichen Feng, Ph.D., Research Associate
HyunJin Kwun, Ph.D., Research Associate
Tuna Toptan, M.D., Ph.D., Postdoctoral Associate
Lindsay Dresang, Ph.D., Postdoctoral Associate
Areas of Interest
Our lab investigates mechanisms of viral oncogenesis using two human tumor viruses we discovered, KSHV and MCV. We are also interested in new human pathogen discovery.
Feng H, Shuda M, Chang Y, and Moore P. S. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 319: 1096-1100. | View Abstract
Chatterjee M, Osborne J, Bestetti G, Chang Y, and Moore P. S. Viral IL-6-induced cell proliferation and immune evasion of interferon activity. Science. 289: 1432-1435. | View Abstract
Sarid R, Sato T, Bohenzky R. A, Russo J. J, Chang Y. Kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. Nat Med. 3: 293-298. | View Abstract
Boshoff C, Endo Y, Collins P. D, Takeuchi Y, Reeves J. D, Schweickart V. L, Siani M. A, Sasaki T, Williams T. J, Gray P. W, Moore P. S, Chang Y, and Weiss R. A. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science. 278: 290-294. | View Abstract
Moore P. S, Boshoff C, Weiss R. A, and Chang Y. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science. 274: 1739-1744. | View Abstract
Chang Y, Moore P. S, Talbot S. J, Boshoff C. H, Zarkowska T, Godden, Kent, Paterson H, Weiss R. A, and Mittnacht S. Cyclin encoded by KS herpesvirus. Nature. 382: 410. | View Abstract
Chang Y, Cesarman E, Pessin M. S, Lee F, Culpepper J, Knowles D. M, Moore P. S. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 266: 1865-1869. | View Abstract